Article

Human placental organoids as a model to probe early gestation maternal immune dynamics

2024-06-06

Abstract excerpt

During pregnancy, the human placenta establishes tolerance toward fetal allogeneic tissue, where specialized trophoblast subtypes play a complex role in local and peripheral immunomodulation. However, due to inadequate models to study the early gestation of the human placenta, each trophoblast subtype's role in modulating the maternal immune response has remained elusive. Here, we derived human placental organoids...

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Literature Corpus work: 494a0a29-5769-52df-8515-a20094cf01c7
DOI: 10.1101/2024.06.05.597501

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