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Article

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis.

Journal of visualized experiments : JoVE - 13 Mar 2026

Tsuda Sayaka, Dasenbrock Angel, Mahajan Shweta, Tilburgs Tamara

Abstract excerpt

The human maternal-fetal interface represents a unique immunological environment where maternal immune cells and fetal extravilllous trophoblasts (EVT) engage in direct cellular contact to establish and maintain immune tolerance. EVT exhibit a distinct immunophenotype characterized by the expression of tolerogenic molecules, including HLA-G, PD-L1, and PD-L2, which play pivotal roles in modulating maternal immune...

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PMID: 41911165
DOI: 10.3791/69545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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