Article

Active Transcriptome Remodeling and Epigenetic Adaptations Underlie Persistence in <i>Leishmania</i> parasites

2026-05-30

Abstract excerpt

<h4>ABSTRACT</h4> Persistence - characterized by the transient ability of subpopulations of drug-susceptible parasites to survive exposure to drug - is a major driver of treatment failure and clinical relapses in leishmaniasis. Persisters are characterized by non-dividing or slow-growing state and increased drug tolerance. However, the molecular mechanisms governing formation of persisters remain poorly understoo...

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Literature Corpus work: 48d75f9b-6a84-53f9-878b-acbfbfdfeacf
DOI: 10.64898/2026.05.29.726936

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