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Article

Long-term hematopoietic stem cells trigger quiescence in <i>Leishmania</i> parasites

2023-08-24

Abstract excerpt

<h4>SUMMARY</h4> Quiescence and posttreatment relapse constitute an important therapeutic constraint across the microbiological spectrum. This study unveils that Leishmania infantum and L. donovani parasites rapidly enter quiescence after an estimated 4-6 divisions in both mouse and human stem cells of the bone marrow but not in macrophages as primary host cells. Quiescent amastigotes display a reduced size and...

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Identifiers and source

Literature Corpus work
921d3d0e-4045-5e5a-833f-a2b32290b553
DOI
10.1101/2023.08.23.554403
Open publication

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Long-term hematopoietic stem cells trigger quiescence in <i>Leishmania</i> parasitesDOI 10.1101/2023.08.23.554403
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