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Gain-of-Function Mutations in <i>PDR1</i> , a Regulator of Antifungal Drug Resistance in Candida glabrata, Control Adherence to Host Cells

5 Mar 2013

Abstract excerpt

Candida glabrata is an emerging opportunistic pathogen that is known to develop resistance to azole drugs due to increased drug efflux. The mechanism consists of CgPDR1-mediated upregulation of ATP-binding cassette transporters. A range of gain-of-function (GOF) mutations in CgPDR1 have been found to lead not only to azole resistance but also to enhanced virulence. This implicates CgPDR1 in the regulation of the...

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PMID: 23460523
DOI: 10.1128/iai.00074-13

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