Article

Hidden route of protein damage through confined oxygen gas

2024-01-04

Abstract excerpt

Oxidative modifications can severely impair protein structure, fold, and function, closely linked to human aging and diseases. Conventional oxidation pathways typically involve the free diffusion of reactive oxygen species (ROS), followed by chemical attacks on the protein surface. Here, we report a hidden route of protein oxidative damage, which we refer to as O 2 -confinement oxidation pathway. This pathway sta...

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Literature Corpus work: eacc2ecc-8179-584d-8edf-69994444a0b2
DOI: 10.1101/2024.01.03.574110

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