Article

Notch Intracellular Domain Plasmid Delivery via Poly(lactic-co-glycolic acid) Nanoparticles to Upregulate Notch Signaling

2021-04-18

Abstract excerpt

Notch signaling is a highly conserved signaling system that is required for embryonic development and regeneration of organs. When the signal is lost, maldevelopment occurs and leads to a lethal state. Liposomes and retroviruses are most commonly used to deliver genetic material to cells. However, there are many drawbacks to these systems such as increased toxicity, nonspecific delivery, short half-life, and stabi...

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Literature Corpus work: 054e2df7-9813-53eb-a8bc-bf96b5712ca7
DOI: 10.1101/2021.04.16.440241

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