Article

Promoting sustainable proliferation of NK cells by up-regulating IL2 and IL12 through CRISPR-CAS9Promoting sustainable proliferation of NK cells by up-regulating IL2 and IL12 through CRISPR-CAS9

2021-03-30

Abstract excerpt

<title>Abstract</title> <p>NK cells are an important part of human immunity and are often used in clinical antitumor adoptive cell immunotherapy.However, the small number and low activity of NK cells in the tumor microenvironment limit its clinical efficacy.Studies have found that cytokines IL2 and IL12 play key roles in the proliferation of NK cells and the improvement of the activity of killing tumor cells, the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 48860f71-a8b8-5000-9f9d-d0ee5f3d5616
DOI: 10.21203/rs.3.rs-317025/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Promoting sustainable proliferation of NK cells by up-regulating IL2 and IL12 through CRISPR-CAS9Promoting sustainable proliferation of NK cells by up-regulating IL2 and IL12 through CRISPR-CAS9DOI 10.21203/rs.3.rs-317025/v1Read

Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cellsSemantic proximity Read

Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potencySemantic proximity Read

Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 RibonucleoproteinsSemantic proximity Read

CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastomaSemantic proximity Read

A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer ImmunotherapySemantic proximity Read

IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILCSemantic proximity Read

Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screensSemantic proximity Read

IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activitySemantic proximity Read

Multiple effects of IL-21 on human NK cells in ex vivo expansionSemantic proximity Read

Cell therapy could benefit from BCG: how anti-tumour BCG-primed NK cells selectively proliferate over other lymphocytes and efficiently kill cancer cellsSemantic proximity Read

CRISPR engineering of armored CAR T cells enables tumor restricted payload delivery with enhanced efficacy and safetySemantic proximity Read

Rational design of immune gene therapy combinations via <i>in vivo</i> CRISPR activation screen of tumor microenvironment modulatorsSemantic proximity Read