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The rabies virus interferon antagonist P protein selectively modulates interferon signalling to inhibit antiviral gene expression while supporting proviral gene expression

2026-07-31

Abstract excerpt

Type-I IFNs mediate the principle antiviral response of cells by controlling the expression of hundreds of IFN-regulated genes (IRGs), many of which have antiviral functions. The best understood mediators of IFN signalling are STAT1 and STAT2, and STAT1/2-dependent gene induction is conventionally viewed as the primary outcome of type-I IFN signalling. To overcome the IFN response, viruses express proteins called...

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Literature Corpus work
47d434f9-7cd8-5d2c-ac3b-148ccff2b5a6
DOI
10.64898/2026.07.30.737726
Open publication

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The rabies virus interferon antagonist P protein selectively modulates interferon signalling to inhibit antiviral gene expression while supporting proviral gene expressionDOI 10.64898/2026.07.30.737726
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