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Autophagy regulator ATG7 links lipid metabolism to cell-fate decisions in kidney tubule health and disease

2025-03-27

Abstract excerpt

Homeostasis in the kidney proximal tubule (PT) requires coordination between metabolism and differentiation, yet the mechanisms governing this balance remain elusive. Here, we integrate model organisms, multiomics profiling, and human genetics to identify the autophagy regulator ATG7 as a key determinant of cell-fate decisions, sustaining PT specialization in health and contributing to dysfunction in disease. In m...

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Literature Corpus work
212379eb-29a5-5242-843b-684e29a17ea5
DOI
10.1101/2025.03.26.25324675
Open publication

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Autophagy regulator ATG7 links lipid metabolism to cell-fate decisions in kidney tubule health and diseaseDOI 10.1101/2025.03.26.25324675
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