Article

Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

2023-01-28

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic intraepithelial neoplasia (PanIN) is a precursor to pancreatic cancer and represents a critical opportunity for cancer interception. However, the number, size, shape, and connectivity of PanINs in human pancreatic tissue samples are largely unknown. In this study, we quantitatively assessed human PanINs using CODA, a novel machine-learning pipeline for 3D image analysis that generates...

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Literature Corpus work: 4796ec4e-443b-5fea-a330-f07c2aa8e555
DOI: 10.1101/2023.01.27.525553

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