3D genomic mapping reveals multifocality of human pancreatic precancers.

doi:10.1038/s41586-024-07359-3

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Article

3D genomic mapping reveals multifocality of human pancreatic precancers.

Nature - 1 May 2024

Braxton Alicia M, Kiemen Ashley L, Grahn Mia P, Forjaz André, Parksong Jeeun, Mahesh Babu Jaanvi, Lai Jiaying, Zheng Lily, Niknafs Noushin, Jiang Liping, Cheng Haixia, Song Qianqian, Reichel Rebecca, Graham Sarah, Damanakis Alexander I, Fischer Catherine G, Mou Stephanie, Metz Cameron, Granger Julie, Liu Xiao-Ding, Bachmann Niklas, Zhu Yutong, Liu YunZhou, Almagro-Pérez Cristina, Jiang Ann Chenyu, Yoo Jeonghyun, Kim Bridgette, Du Scott, Foster Eli, Hsu Jocelyn Y, Rivera Paula Andreu, Chu Linda C, Liu Fengze, Fishman Elliot K, Yuille Alan, Roberts Nicholas J, Thompson Elizabeth D, Scharpf Robert B, Cornish Toby C, Jiao Yuchen, Karchin Rachel, Hruban Ralph H, Wu Pei-Hsun, Wirtz Denis, Wood Laura D

Abstract excerpt

Pancreatic intraepithelial neoplasias (PanINs) are the most common precursors of pancreatic cancer, but their small size and inaccessibility in humans make them challenging to study1. Critically, the number, dimensions and connectivity of human PanINs remain largely unknown, precluding important insights into early cancer development. Here, we provide a microanatomical survey of human PanINs by analysing 46 large...

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PMID: 38693266
DOI: 10.1038/s41586-024-07359-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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