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Quantitative modeling of SARS-CoV-2 replication reveals phase-specific bottlenecks and antiviral targets

2026-06-24

Abstract excerpt

SARS-CoV-2 replication depends on a tightly coordinated series of intracellular processes that remain incompletely quantified. Here, we integrated high-resolution time-resolved measurements of viral RNA, protein expression, and infectious virion production with mechanistic mathematical modeling to obtain a quantitative description of the viral replication cycle in human lung cells. Using transcriptomic, proteomic,...

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Literature Corpus work
4792ac64-6d3a-54ee-9967-588f1f64bc7a
DOI
10.64898/2026.06.23.733955
Open publication

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Quantitative modeling of SARS-CoV-2 replication reveals phase-specific bottlenecks and antiviral targetsDOI 10.64898/2026.06.23.733955
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