Article

Pathologic gene network rewiring implicates PPP1R3A as a central cardioprotective factor in pressure overload heart failure

2016-01-28

Abstract excerpt

Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvested 1352 healthy and failing human hearts directly from transplant center operating rooms, and obtained genome-wide genotyping and gene expression measurements for a subset of 313. We built failing and non-failing cardiac regulatory gene networks, revealing imp...

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Identifiers and source

Literature Corpus work: 47806b6a-c809-5319-8d78-f8ce47dc99b9
DOI: 10.1101/038174

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