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Layered Functional Network Analysis of Gene Expression in Human Heart Failure

23 Jul 2009

Abstract excerpt

BACKGROUND: Although dilated cardiomyopathy (DCM) is a leading cause of heart failure (HF), the mechanism underlying DCM is not well understood. Previously, it has been demonstrated that an integrative analysis of gene expression and protein-protein interaction (PPI) networks can provide insights into the molecular mechanisms of various diseases. In this study we develop a systems approach by linking public...

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PMID: 19629191
DOI: 10.1371/journal.pone.0006288

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