Article

Mutability of Druggable Kinases and Pro-inflammatory Cytokines by Their Proximity to Telomeres and A+T Content

2021-11-15

Abstract excerpt

Mutations of protein kinases are common and can cause cancer and other diseases. However, our understanding of the mutability in genes encoding kinases remains rudimentary. Given previously proposed factors associated with high mutation rates, we analyzed how many genes encoding druggable kinases match with (i) proximity to telomeres or (ii) high A+T content. We extracted genomic information using National Institu...

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Literature Corpus work: 477ab67a-bf04-57f2-8a1c-91bfd3ed708a
DOI: 10.21203/rs.3.rs-1057987/v1

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