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GOF Mutant p53 in Cancers: A Therapeutic Challenge

18 Oct 2022

Abstract excerpt

is mutated in the majority of human cancers. Mutations can lead to loss of p53 expression or expression of mutant versions of the p53 protein. These mutant p53 proteins have oncogenic potential. They can inhibit any remaining WTp53 in a dominant negative manner, or they can acquire new functions that promote tumour growth, invasion, metastasis and chemoresistance. In this review we explore some of the mechanisms...

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PMID: 36291874
DOI: 10.3390/cancers14205091

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