Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased mitochondrial mass in mitochondrial myopathy mice

4 Nov 2002

Abstract excerpt

We have generated an animal model for mitochondrial myopathy by disrupting the gene for mitochondrial transcription factor A (Tfam) in skeletal muscle of the mouse. The knockout animals developed a myopathy with ragged-red muscle fibers, accumulation of abnormally appearing mitochondria, and progressively deteriorating respiratory chain function in skeletal muscle. Enzyme histochemistry, electron micrographs, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Metabolism and Genetic Disorders
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12417746
DOI: 10.1073/pnas.232591499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased mitochondrial mass in mitochondrial myopathy micePMID 12417746Read ↗

How is Mitochondrial Biogenesis Affected in Mitochondrial Disease?Semantic proximity Read ↗

Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies.Semantic proximity Read ↗

Fast skeletal muscle troponin activator in the dy2J muscular dystrophy model.Semantic proximity Read ↗

TFAM-deficient mouse skin fibroblasts – an ex vivo model of mitochondrial dysfunctionSemantic proximity Read ↗

Mitochondria in motor nerve terminals: function in health and in mutant superoxide dismutase 1 mouse models of familial ALS.Semantic proximity Read ↗

Cyclophilin D, a target for counteracting skeletal muscle dysfunction in mitochondrial myopathy.Semantic proximity Read ↗

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.Semantic proximity Read ↗

Creatine kinase knockout mice--what is the phenotype: skeletal muscle.Semantic proximity Read ↗

Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice.Semantic proximity Read ↗

Peroxisome proliferator‐activated receptor γ coactivator 1‐α gene transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post‐necrotic mdx mouse skeletal muscleSemantic proximity Read ↗

Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies.Semantic proximity Read ↗

Increased susceptibility to fatigue of slow- and fast-twitch muscles from mice lacking the MG29 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.