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Article

Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice.

Human molecular genetics - 31 May 2021

Nogami Ken'ichiro, Maruyama Yusuke, Sakai-Takemura Fusako, Motohashi Norio, Elhussieny Ahmed, Imamura Michihiro, Miyashita Satoshi, Ogawa Megumu, Noguchi Satoru, Tamura Yuki, Kira Jun-Ichi, Aoki Yoshitsugu, Takeda Shin'ichi, Miyagoe-Suzuki Yuko

Abstract excerpt

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder characterized by progressive muscular weakness because of the loss of dystrophin. Extracellular Ca2+ flows into the cytoplasm through membrane tears in dystrophin-deficient myofibers, which leads to muscle contracture and necrosis. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) takes up cytosolic Ca2+ into the sarcoplasmic reticulum, but its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33822956
DOI: 10.1093/hmg/ddab100
PMCID: PMC8170845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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