Article

Lifespan analysis of dystrophic <i>mdx</i> fast-twitch muscle morphology and its impact on contractile function

2021-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Duchenne muscular dystrophy is caused by the absence of the protein dystrophin from skeletal muscle and is characterized by progressive cycles of necrosis/regeneration. Using the dystrophin deficient mdx mouse model we studied the morphological and contractile chronology of dystrophic skeletal muscle pathology in fast twitch EDL muscles from animals 4-22 months of age containing 100% regenerate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb6b6ae2-15a1-58aa-91cd-9040f8b3b889
DOI: 10.1101/2021.09.07.459226

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lifespan analysis of dystrophic <i>mdx</i> fast-twitch muscle morphology and its impact on contractile functionDOI 10.1101/2021.09.07.459226Read

Dystrophin-negative slow-twitch soleus muscles are not susceptible to eccentric contraction induced injury over the lifespan of the mdx mouse.Semantic proximity Read

Trained to repair: repeated muscle injury imprints a ‘healthy regenerative memory’Semantic proximity Read

Transcriptomic analysis of mdx mouse muscles reveals a signature of early human Duchenne muscular dystrophySemantic proximity Read

Histological Methods to Assess Skeletal Muscle Degeneration and Regeneration in Duchenne Muscular DystrophySemantic proximity Read

Enhanced skeletal muscle fatigue tolerance through cell transplantation-mediated dystrophin supplementation in a mouse model of Duchenne Muscular DystrophySemantic proximity Read

Profiling of Age-Related Changes in the<i>Tibialis Anterior</i>Muscle Proteome of the mdx Mouse Model of DystrophinopathySemantic proximity Read

Mitochondrial dysfunction is an early consequence of partial or complete dystrophin loss in mdx mice.Semantic proximity Read

Rewiring Fibroblast–Muscle Axis Drives Progressive Pathology in Bethlem MyopathySemantic proximity Read

The skeletal muscle phenotype of the DE50-MD dog model of Duchenne muscular dystrophySemantic proximity Read

Bioengineered 3D Skeletal Muscle Model Reveals Complement 4b as a Cell‐Autonomous Mechanism of Impaired Regeneration with AgingSemantic proximity Read

Dystrophin-deficient zebrafish feature aspects of the Duchenne muscular dystrophy pathology.Semantic proximity Read

Fibrosis development in early-onset muscular dystrophies: Mechanisms and translational implicationsSemantic proximity Read