Article

Integrated multiomics reveals inflammation-driven excessive erythrocytosis in subjects with Monge’s disease

2025-10-21

Abstract excerpt

Monge’s disease, or Chronic Mountain Sickness (CMS), is a chronic high-altitude disorder characterized by hypoxia-induced excessive erythrocytosis (EE), elevating the risk of stroke and myocardial infarction. Using RNA-seq and ATAC-seq, we profiled iPSC-derived erythroid cells from CMS and non-CMS subjects under normoxia and hypoxia to identify statistically significant, disease-associated transcriptional and chro...

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Literature Corpus work: 475f17c4-3409-5aa9-9f05-01c1eb09c9fd
DOI: 10.1101/2025.10.20.683487

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