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The human blood transcriptome exhibits time-of-day-dependent response to hypoxia: Lessons from the highest city in the world

1 Aug 2022

Abstract excerpt

High altitude exposes humans to hypobaric hypoxia, which induces various physiological and molecular changes. Recent studies point toward interaction between circadian rhythms and the hypoxic response, yet their human relevance is lacking. Here, we examine the effect of different high altitudes in conjunction with time of day on human whole-blood transcriptome upon an expedition to the highest city in the world,...

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PMID: 35977481
DOI: 10.1016/j.celrep.2022.111213

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