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Article

EPAS1 regulates proliferation of erythroblasts in chronic mountain sickness

19 May 2020

Abstract excerpt

Excessive erythrocytosis (EE) is a characteristic of chronic mountain sickness (CMS). Currently, the pathogenesis of CMS remains unclear. This study was intended to investigate the role of EPAS1 in the proliferation of erythroblasts in CMS. Changes of HIF-1α and EPAS1/HIF-2α in the bone marrow erythroblasts of 21 patients with CMS and 14 control subjects residing at the same altitudes were determined by RT-qPCR...

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PMID: 32470757
DOI: 10.1016/j.bcmd.2020.102446

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