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Whole transcriptome landscape in HAPE under the stress of environment at high altitudes: new insights into the mechanisms of hypobaric hypoxia tolerance

12 Sept 2024

Abstract excerpt

Background: High altitude pulmonary edema (HAPE) is an idiopathic, noncardiogenic form of pulmonary edema that occurs at high altitudes. It is characterized by a severe clinical course and carries a significant mortality risk. Despite its clinical relevance, the molecular mechanisms underlying HAPE are not well understood. Methods: We conducted whole-transcriptome RNA sequencing on blood samples from 6 pairs of...

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PMID: 39328420
DOI: 10.3389/fimmu.2024.1444666

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