Article

A DNA damage response-like phenotype defines a novel subset of colon cancer

2022-07-29

Abstract excerpt

<title>Abstract</title> <p>Colon adenocarcinoma (COAD) has a limited range of diversified, personalized therapeutic opportunities, besides DNA hypermutating cases; thus both new targets or broadening existing strategies for personalized intervention are of interest. Routinely processed material from 246 untreated COADs with clinical follow-up was probed for evidence of DNA damage response (DDR) by multiplex immun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 475a6113-2cb5-5cb4-83c0-8aff2c50c969
DOI: 10.21203/rs.3.rs-1868531/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A DNA damage response-like phenotype defines a novel subset of colon cancerDOI 10.21203/rs.3.rs-1868531/v1Read

A DNA damage response-like phenotype defines a third of colon cancers at onset.Semantic proximity Read

POLE-mutant colon adenocarcinoma – case presentation and histopathological evaluationSemantic proximity Read

Comprehensive characterization of PKHD1 mutation in human colon cancer.Semantic proximity Read

COX-2 regulates IL-17A-producing γδ T cells to drive mismatch repair-deficient colon cancerSemantic proximity Read

The Good, the Bad and the Ugly - Novel Synoptic Variables in the Personalisation of Colon Cancer TreatmentSemantic proximity Read

DNA repair capacity and response to treatment of colon cancer.Semantic proximity Read

Establishment, characterization and chemosensitivity of three mismatch repair deficient cell lines from sporadic and inherited colorectal carcinomas.Semantic proximity Read

POLE-Mutant Colon Adenocarcinoma-Case Presentation and Histopathological Evaluation.Semantic proximity Read

A commentary on the article "Prevalence of the mismatch repair-deficient phenotype in colonic adenomas arising in HNPCC patients--results of a 5-year follow-up study".Semantic proximity Read

DNA mismatch repair protein deficient non-neoplastic colonic crypts: a novel indicator of Lynch syndromeSemantic proximity Read

Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal CarcinomasSemantic proximity Read

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitorsSemantic proximity Read