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Article

A DNA damage response-like phenotype defines a third of colon cancers at onset.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2023

Mauro Stefania, Bolognesi Maddalena M, Villa Nicoletta, Capitoli Giulia, Furia Laura, Mascadri Francesco, Zucchini Nicola, Totis Mauro, Faretta Mario, Galimberti Stefania, Bovo Giorgio, Cattoretti Giorgio

Abstract excerpt

Colon adenocarcinoma (COAD) has a limited range of diversified, personalized therapeutic opportunities, besides DNA hypermutating cases; thus, both new targets or broadening existing strategies for personalized intervention are of interest. Routinely processed material from 246 untreated COADs with clinical follow-up was probed for evidence of DNA damage response (DDR), that is, the gathering of DDR-associated...

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Identifiers

PMID: 37342943
DOI: 10.1096/fj.202300132R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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