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Article

Establishment, characterization and chemosensitivity of three mismatch repair deficient cell lines from sporadic and inherited colorectal carcinomas.

PloS one - 1 Jan 2012

Maletzki Claudia, Stier Saskia, Gruenert Ulrike, Gock Michael, Ostwald Christiane, Prall Friedrich, Linnebacher Michael

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) represents a morphologic and molecular heterogenic disease. This heterogeneity substantially impairs drug effectiveness and prognosis. The subtype of mismatch repair deficient (MMR-D) CRCs, accounting for about 15% of all cases, shows particular differential responses up to resistance towards currently approved cytostatic drugs. Pre-clinical in vitro models representing...

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Identifiers

PMID: 23300683
DOI: 10.1371/journal.pone.0052485
PMCID: PMC3534085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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