Article

Genetic signature of prostate cancer resistant to optimized hK2 targeted alpha-particle therapy

2019-09-02

Abstract excerpt

Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate specific enzyme human kallikrein 2 (hK2; KLK2 ). In multiple rodent models, Actinium-225 labeled hu11B6-IgG 1 ([ 225 Ac]hu11B6-IgG 1 ) has shown promising treatment efficacy. In the current study we investigated options to enhance and optimize [ 225 Ac]hu11B6 treatment. Firstly, we evaluated the pos...

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Literature Corpus work: 47423105-2b42-5892-8b8a-f6a9f7965abd
DOI: 10.1101/754036

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