Article
Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis.
Science translational medicine - 30 Nov 2016
Thorek Daniel L J, Watson Philip A, Lee Sang-Gyu, Ku Anson T, Bournazos Stylianos, Braun Katharina, Kim Kwanghee, Sjöström Kjell, Doran Michael G, Lamminmäki Urpo, Santos Elmer, Veach Darren, Turkekul Mesruh, Casey Emily, Lewis Jason S, Abou Diane S, van Voss Marise R H, Scardino Peter T, Strand Sven-Erik, Alpaugh Mary L, Scher Howard I, Lilja Hans, Larson Steven M, Ulmert David
Abstract excerpt
Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. AR-regulated...
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