Article

Assessing Functional Androgen Receptor Pathway Activity in Response to Radiotherapy Using hK2-targeted PET Imaging

2022-06-26

Abstract excerpt

External beam radiotherapy (EBRT) remains a common treatment for all stages of PCa, but DNA damage induced by EBRT upregulates androgen receptor (AR) pathway activity to promote therapeutic resistance. [ 89 Zr]11B6-PET is a novel modality targeting prostate-specific protein human kallikrein 2 (hK2), which is a surrogate biomarker for AR activity. Here, we studied if [ 89 Zr]11B6-PET can accurately assess EBRT-in...

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Literature Corpus work: 9c6faaee-3f3f-5923-96ba-75dfa7efd99d
DOI: 10.1101/2022.06.23.497290

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