Article

Guiding treatment response by spatiotemporal control of α-particle deposition in solid tumors: the case for ‘affinity cocktails’ of antibody-radioconjugates

2025-12-25

Abstract excerpt

Antibody-radioconjugates are leading the investigational targeted alpha-particle (α-particle) therapies for the treatment of solid tumors that do not respond to approved therapies. Yet, there is still treatment failure in the clinic largely attributed to the heterogenous patterns of tumor irradiation by α-particles. Although α-particles are essentially impervious to resistance, attributed to the complex double-str...

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Literature Corpus work: 64308d4c-294c-5b57-838e-e4f024e76e88
DOI: 10.64898/2025.12.22.696075

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