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Article

BACE is degraded via the lysosomal pathway.

The Journal of biological chemistry - 16 Sept 2005

Koh Young Ho, von Arnim Christine A F, Hyman Bradley T, Tanzi Rudolph E, Tesco Giuseppina

Abstract excerpt

Amyloid plaques are formed by aggregates of amyloid-beta-peptide, a 37-43-amino acid fragment (primarily Abeta(40) and Abeta(42)) generated by proteolytic processing of the amyloid precursor protein (APP) by beta- and gamma-secretases. A type I transmembrane aspartyl protease, BACE (beta-site APP cleaving enzyme), has been identified to be the beta-secretase. BACE is targeted through the secretory pathway to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16033761
DOI: 10.1074/jbc.M506199200

Genes

APP
LAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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