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Article

Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.

The Journal of biological chemistry - 1 Nov 1996

Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De Strooper B

Abstract excerpt

betaA4-Amyloid peptide, the main component of the amyloid plaques in the brain of Alzheimer's disease patients is produced from amyloid precursor protein (APP) by proteolytical processing. Several lines of evidence suggest a direct role for cathepsin D, the major endosomal/lysosomal aspartic endo...

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Identifiers

PMID: 8910296
DOI: 10.1074/jbc.271.44.27241

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8910296-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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