Article

Evidence for the digital programming of cellular differentiation: characterization of binary switches in lineage-determining transcription factors

2022-06-24

Abstract excerpt

Previous studies of the murine Ly49 and human KIR gene clusters have revealed a role for bidirectional promoters in the control of variegated gene expression. Whether or not competing promoters control other instances of cell fate determination remains an outstanding question. Although divergent transcripts within 300 bp are found in ~6% of human genes, an analysis of human transcription factor (TF) genes (1640)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 47136822-4325-5f78-bdc0-0e5de0721163
DOI: 10.1101/2022.06.22.497234

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evidence for the digital programming of cellular differentiation: characterization of binary switches in lineage-determining transcription factorsDOI 10.1101/2022.06.22.497234Read

Role of Transcription Factors in Differentiation and Reprogramming of Hematopoietic CellsSemantic proximity Read

Deciphering transcriptional networks during human cardiac developmentSemantic proximity Read

Interactions with single-stranded and double-stranded DNA-binding factors and alternative promoter conformation upon transcriptional activation of the Htf9-a/RanBP1 and Htf9-c genes.Semantic proximity Read

Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching.Semantic proximity Read

Bidirectional promoters regulate the monoallelically expressed Ly49 NK receptors.Semantic proximity Read

Intercellular network structure and regulatory motifs in the human hematopoietic systemSemantic proximity Read

Transcription factor and cytokine regulation of eosinophil lineage commitmentSemantic proximity Read

Cell fate determination is associated with changes in competing transcriptional units in the human <i>GATA1</i> and <i>GATA2</i> lineage-determining transcription factorsSemantic proximity Read

Atlas of Regulated Target Genes of Transcription Factors (ART-TF) in Human ES CellsSemantic proximity Read

High temporal resolution RNA-seq time course data reveals mammalian lncRNA activation mirrors neighbouring protein-coding genesSemantic proximity Read

Molecular Evidence for Hierarchical Transcriptional Lineage Priming in Fetal and Adult Stem Cells and Multipotent ProgenitorsSemantic proximity Read

Modeling and visualizing cell type switching.Semantic proximity Read