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Cell fate determination is associated with changes in competing transcriptional units in the human <i>GATA1</i> and <i>GATA2</i> lineage-determining transcription factors

2024-11-09

Abstract excerpt

The GATA1 and GATA2 transcription factors play a central role in early cell fate decisions in hematopoietic progenitor cells. Although the switch from GATA2 to GATA1 occupancy at GATA-binding sites in erythroblast-specific genes has been extensively studied, the underlying molecular mechanisms controlling this switch are not fully elucidated. An antisense promoter in the 5’ region of the GATA2 gene produces a lon...

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Literature Corpus work
101b547f-2ec0-518f-91c2-be1d25d4a549
DOI
10.1101/2024.11.08.622131
Open publication

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Cell fate determination is associated with changes in competing transcriptional units in the human <i>GATA1</i> and <i>GATA2</i> lineage-determining transcription factorsDOI 10.1101/2024.11.08.622131
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