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Article

The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening.

Proteins - 1 Dec 2018

Wells Gordon, Yuan Hongjie, McDaniel Miranda J, Kusumoto Hirofumi, Snyder James P, Liotta Dennis C, Traynelis Stephen F

Abstract excerpt

N-methyl-D-aspartate (NMDA) receptors are transmembrane glutamate-binding ion channels that mediate neurotransmission in mammals. NMDA receptor subunits are tetrameric complexes of GluN1 and GluN2A-D subunits, encoded by the GRIN gene family. Of these subunits, GluN2B is suggested to be required for normal development of the central nervous system. A mutation identified in a patient with developmental delay,...

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PMID: 30168177
DOI: 10.1002/prot.25595
PMCID: PMC6774441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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