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Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression

14 Jul 2015

Abstract excerpt

UNLABELLED: Many cancer cells require more glycolytic adenosine triphosphate production due to a mitochondrial respiratory defect. However, the roles of mitochondrial defects in cancer development and progression remain unclear. To address the role of transcriptomic regulation by mitochondrial defects in liver cancer cells, we performed gene expression profiling for three different cell models of mitochondrial...

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PMID: 26173068
DOI: 10.1002/hep.27976

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