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The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis.

Human molecular genetics - 1 Jun 2010

Gandhi Kaushal S, McKay Fiona C, Cox Mathew, Riveros Carlos, Armstrong Nicola, Heard Robert N, Vucic Steve, Williams David W, Stankovich Jim, Brown Matthew, Danoy Patrick, Stewart Graeme J, Broadley Simon, Moscato Pablo, Lechner-Scott Jeannette, Scott Rodney J, Booth David R

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease with a genetic component, caused at least in part by aberrant lymphocyte activity. The whole blood mRNA transcriptome was measured for 99 untreated MS patients: 43 primary progressive MS, 20 secondary progressive MS, 36 relapsing remitting MS and 45 age-matched healthy controls. The ANZgene Multiple Sclerosis Genetics Consortium genotyped more than 300 000 SNPs for...

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Antigen Presentation
CD40 Antigens
Chromosomes, Human, Pair 12
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Multiple Sclerosis

Oxidative Phosphorylation

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PMID: 20190274
DOI: 10.1093/hmg/ddq090

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