Article
Functional genomic analysis reveals overlapping and distinct features of chronologically long-lived yeast populations.
Aging - 1 Mar 2015
Wierman Margaret B, Matecic Mirela, Valsakumar Veena, Li Mingguang, Smith Daniel L, Bekiranov Stefan, Smith Jeffrey S
Abstract excerpt
Yeast chronological lifespan (CLS) is extended by multiple genetic and environmental manipulations, including caloric restriction (CR). Understanding the common changes in molecular pathways induced by such manipulations could potentially reveal conserved longevity mechanisms. We therefore performed gene expression profiling on several long-lived yeast populations, including anade4∆mutant defective in de novo...
Topics
- Biomarkers
- Caloric Restriction
- Culture Media, Conditioned
- Gene Expression Profiling
- Mutation
- Niacinamide
- Saccharomyces cerevisiae