Article

VEGFR2 blockade converts thermally ablative focused ultrasound into a potent driver of T cell-dependent anti-tumor immunity

2025-10-24

Abstract excerpt

Thermally ablative focused ultrasound (TFUS) can induce favorable immune signatures in solid tumors but rarely generates durable systemic immunity or enhances checkpoint inhibition. We tested whether combining TFUS with aVEGFR2, which normalizes tumor vasculature and remodels immune cell composition, triggers T cell–dependent immunity and synergizes with checkpoint inhibition. Subtotal TFUS (∼40% volumetric ablati...

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Identifiers and source

Literature Corpus work: 46e205fa-0c09-569b-a04f-90814d7751bc
DOI: 10.1101/2025.10.23.683708

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