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Article

Sustained release hydrogel for durable locoregional chemoimmunotherapy for BRAF-mutated melanoma.

Journal of controlled release : official journal of the Controlled Release Society - 1 May 2023

Kim Jihoon, Archer Paul A, Manspeaker Margaret P, Avecilla Alexa R C, Pollack Brian P, Thomas Susan N

Abstract excerpt

The wide prevalence of BRAF mutations in diagnosed melanomas drove the clinical advancement of BRAF inhibitors in combination with immune checkpoint blockade for treatment of advanced disease. However, deficits in therapeutic potencies and safety profiles motivate the development of more effective strategies that improve the combination therapy's therapeutic index. Herein, we demonstrate the benefits of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37080489
DOI: 10.1016/j.jconrel.2023.04.028
PMCID: PMC10328138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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