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<i>Toxoplasma</i> surface coat protein TgSRS57 (TgSAG3) regulates complement deposition, Factor H recruitment, and promotes parasite persistence

2022-10-17

Abstract excerpt

<h4>ABSTRACT</h4> The surface coat of Toxoplasma gondii possesses a lectin-like activity that activates host complement. Serum resistance relies on specific recruitment of host regulators Factor H (FH) and C4BP to the parasite surface to inactivate bound C3 and evade the complement system. TgSRS57 (TgSAG3) was previously reported to possess a lectin-like activity specific for sulfated proteoglycans (SPGs) that f...

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Literature Corpus work
46d7160b-c682-5b2f-be4b-4c28ec08ba09
DOI
10.1101/2022.10.17.512461
Open publication

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