Article

The GPI sidechain of <i>Toxoplasma gondii</i> prevents parasite pathogenesis

2024-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Glycosylphosphatidylinositols (GPIs) are highly conserved anchors for eukaryotic cell surface proteins. The apicomplexan parasite, Toxoplasma gondii , is a widespread intracellular parasite of warm-blooded animals whose plasma membrane is covered with GPI-anchored proteins, and free GPIs called GIPLs. While the glycan portion is conserved, species differ in sidechains added to the triple mannos...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bdee14f7-a0b8-5f71-b137-0d8508381016
DOI: 10.1101/2024.02.21.581431

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The GPI sidechain of <i>Toxoplasma gondii</i> prevents parasite pathogenesisDOI 10.1101/2024.02.21.581431Read

When more sugar is better-a GPI side chain modification results in a less virulent phenotype during a protozoan infection.Semantic proximity Read

Targeting the GPI biosynthetic pathwaySemantic proximity Read

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in <i>Trypanosoma brucei</i>Semantic proximity Read

Enabling tools for <i>Toxoplasma</i> glycobiologySemantic proximity Read

<i>Toxoplasma</i> surface coat protein TgSRS57 (TgSAG3) regulates complement deposition, Factor H recruitment, and promotes parasite persistenceSemantic proximity Read

Making Home Sweet and Sturdy:<i>Toxoplasma gondii</i>ppGalNAc-Ts Glycosylate in Hierarchical Order and Confer Cyst Wall RigiditySemantic proximity Read

The lectin-specific activity of <i>Toxoplasma gondii</i> microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune primingSemantic proximity Read

Genes for Glycosylphosphatidylinositol Toxin Biosynthesis inPlasmodium falciparumSemantic proximity Read

Detection of Antibodies Against the African Parasite <i>Trypanosoma brucei</i> Using Synthetic glycosylphosphatidylinositol oligosaccharide fragmentsSemantic proximity Read

Unveiling the Sugary Secrets of Plasmodium ParasitesSemantic proximity Read

Dense granule protein, GRA64 interacts with host cell ESCRT proteins during <i>Toxoplasma gondii</i> infectionSemantic proximity Read

VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathologySemantic proximity Read