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The delayed bloodstream clearance of <i>Plasmodium falciparum</i> parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts

2023-04-24

Abstract excerpt

M5717 is a promising antimalarial drug under development thatacts against multiple stages of the life cycle of Plasmodium parasites by inhibiting the translation elongation factor 2 ( Pf eEF2), thereby preventing protein synthesis. The parasite clearance profile after drug treatment in preclinical studies in mice, and clinical trials in humans showed a notable delayed clearance phenotype whereby parasite infecte...

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Literature Corpus work
af6dcdeb-bc84-5252-b6fc-bb168f736394
DOI
10.1101/2023.04.24.538013
Open publication

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