Article

Mistranslation and ageing unmask FUS and TDP-43 toxicity in yeast models of neurodegenerative diseases

2025-05-13

Abstract excerpt

<title>Abstract</title> <p>Protein aggregation is indicative of the loss of proteostasis associated with neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Proteins like Fused in sarcoma (FUS) and Tar DNA-binding protein 43 (TDP-43) accumulate and aggregate in the cytosol of neurons in ALS/FTD. Yet, it remains unclear how ageing affects FUS and TDP-43 aggr...

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Literature Corpus work: 46b48832-a0ce-5272-8833-b0aa6a5c8c56
DOI: 10.21203/rs.3.rs-6448360/v1

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