Article

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

2023-10-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Significance Statement</h4> ONECUT2 (OC2) is a master transcription factor that alters lineage identity by activating gene networks associated with both neuroendocrine prostate cancer and prostate adenocarcinoma. A small molecule inhibitor of OC2 represses the lineage plasticity program activated by enzalutamide, suggesting OC2 inhibition as a novel therapeutic strategy to prevent emergence...

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Literature Corpus work: 46b08625-f4c1-5b3d-a2c6-46e930505ce1
DOI: 10.1101/2023.09.28.560025

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