Article

Loss of bisecting GlcNAcylation on MCAM of bone marrow stoma determined pro-tumoral niche in MDS/AML

2022-06-22

Abstract excerpt

<title>Abstract</title> <p>Bone marrow (BM) stroma plays key roles in supporting hematopoietic stem cell (HSC) growth. Glycosylation contributes to the interactions between HSC and surrounding microenvironment. We observed that bisecting N-acetylglucosamine (GlcNAc) structures, in BM stromal cells were significantly lower for MDS/AML patients than for healthy subjects. Malignant clonal cells delivered exosomal mi...

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Literature Corpus work: 4695b0fd-7fc9-508a-87da-819a9310c66c
DOI: 10.21203/rs.3.rs-1749849/v1

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