Article

Integrated analyses of single-cell RNA-seq public data reveal the gene regulatory network landscape of respiratory epithelial and peripheral immune cells in COVID-19 patients

2023-03-10

Abstract excerpt

<h4>Introduction</h4> Infection with SARS-CoV-2 leads to coronavirus disease 2019 (COVID-19), which can result in acute respiratory distress syndrome and multiple organ failure. However, its comprehensive influence on pathological immune responses in the respiratory epithelium and peripheral immune cells is not yet fully understood. <h4>Methods</h4> In this study, we integrated multiple public scRNA-seq datasets o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99908e7b-8a37-5d58-866d-2d350fa65836
DOI: 10.1101/2023.03.09.23287043

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated analyses of single-cell RNA-seq public data reveal the gene regulatory network landscape of respiratory epithelial and peripheral immune cells in COVID-19 patientsDOI 10.1101/2023.03.09.23287043Read

Transcriptomic dysregulations associated with SARS-CoV-2 infection in human nasopharyngeal and peripheral blood mononuclear cellsSemantic proximity Read

An Integrative Analysis Identifying Transcriptional Features and key Genes Involved in COVID-19Semantic proximity Read

The current status of gene expression profilings in COVID‐19 patientsSemantic proximity Read

Comparative transcriptomic analyses of peripheral blood mononuclear cells of patients with non-pneumonia and severe pneumonia at 1 year-Long-COVID-19Semantic proximity Read

Molecular signatures in the progression of COVID-19 severitySemantic proximity Read

Expansion of Single Cell Transcriptomics Data of SARS-CoV Infection in Human Bronchial Epithelial Cells to COVID-19Semantic proximity Read

Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19Semantic proximity Read

Transcriptional analysis of lung epithelial cells using WGCNA revealed the role of IRF9 and IFI6 genes in SARS-CoV-2 pathogenicitySemantic proximity Read

Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19Semantic proximity Read

SARS-CoV-2 activates lung epithelia cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients by single-cell sequencingSemantic proximity Read

Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolutionSemantic proximity Read

Integrated Transcriptomic Analysis Reveals Distinct Immune Response Signatures and Prognostic Biomarkers in SARS-CoV-2 InfectionSemantic proximity Read