Back to search

Article

Gene regulatory networks define human airway epithelial cell types and their distinct responses to type I interferon

2026-05-13

Abstract excerpt

The human airway epithelium (HAE) is composed of diverse cell types that coordinate essential functions and host defenses. Among these defenses, interferons (IFNs) are central to antiviral programs. However, the gene regulatory networks (GRNs) governing HAE cellular identities and their IFN responses are incompletely defined. At single-cell resolution, we characterized the transcriptomes and accessible chromatin l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4b96d746-177a-591b-9547-0e34476f15cc
DOI
10.64898/2026.05.09.724010
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Gene regulatory networks define human airway epithelial cell types and their distinct responses to type I interferonDOI 10.64898/2026.05.09.724010
A Single-Cell Atlas of the Human Healthy AirwaysSemantic proximity
A comparative study of in vitro air–liquid interface culture models of the human airway epithelium evaluating cellular heterogeneity and gene expression at single cell resolutionSemantic proximity
Transcriptional Roadmap of the Human Airway Epithelium Identifying HLF as a Novel Regulator of Basal Stem Cell FunctionSemantic proximity
A single-cell atlas of the human healthy airwaysSemantic proximity
Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesisSemantic proximity
A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and diseaseSemantic proximity
Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesisSemantic proximity
Characterizing cellular heterogeneity in fibrotic hypersensitivity pneumonitis by single-cell transcriptional analysisSemantic proximity
Long-read single-cell RNA sequencing uncovers cell-type specific transcript regulation in COVID-19Semantic proximity
A comparative study of <i>in vitro</i> air-liquid interface culture models of the human airway epithelium evaluating cellular heterogeneity and gene expression at single cell resolutionSemantic proximity
BATF promotes group 2 innate lymphoid cell–mediated lung tissue protection during acute respiratory virus infectionSemantic proximity
Epithelial and immune transcriptomic characteristics and possible regulatory mechanisms in asthma exacerbation: insights from integrated studiesSemantic proximity
Select a neighboring publication to make it the new centre.