Article

Amyotrophic lateral sclerosis: Protein chaperone dysfunction revealed by proteomic studies of animal models.

2008-05-01

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons and causes progressive muscle weakness and atrophy. The etiology and pathogenesis of ALS are largely unknown and no effective treatment is presently available. About 10% of patients have the familial or inherited form of the disease (fALS), among which 20% is linked to mutations with Cu2+/Zn2+ superoxide dismutase (...

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Literature Corpus work: 468c4da2-90ad-55fd-a93a-01ae423716db
DOI: 10.1002/prca.200780023

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